General and Systemic Pathology (Etiology and Pathogenesis)

Shinya TOYOKUNI Professor

Department: School of Medicine / Graduate School of Medicine

Class Time: 2015 Spring Monday Tuesday Wednesday Thursday Friday
Recommended for: 3rd year students in medical school

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Course Overview

Pathology is one of the core lectures in medical school. Medical students are required to learn medical terminology of all diseases from head to toe and their definitions and concepts. Thus, pathology is a link between basic and clinical medicine. This class consists of general pathology, systemic pathology and case studies (clinicopathological example).

Key Features

Understanding normal anatomic and histological structures (anatomy and histology) is a prerequisite for this course, and students will learn the concepts and terminology associated with human diseases. In general pathology, students will learn the general concepts of etiology and pathogenesis, based on current and cutting-edge science, to understand cellular degeneration and death, organ failure and neoplasm. Free radical biology, cellular signaling based on molecular biology, genetic traits and environmental factors are fully considered. We also stress the importance of morphological alterations based on pattern recognition. After general pathology, students can classify all kinds of diseases into one of these categories including degenerative, circulatory disturbance, inflammatory (infectious or autoimmune), neoplastic or others.

In systemic biology, forefront pathologists give lectures on major or important diseases in each system. Half of the lectures are laboratory training using either microscope or virtual slide system through computers. For these training, typical clinical cases are given.

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Objective of the Courses

At the end of this course, students will be able to understand all major concepts of human diseases and the corresponding terminology, and classify the diseases based on its etiology. Students will learn the typical macroscopic and microscopic findings of all the major human diseases, and will be able to diagnose major diseases under microscope.


The followings are recommended.

  1. Kumar, Abbas, Fausto, Mitchell: Robbins Basic Pathology 9th edition, Elsevier, 2013; we edited the Japanese translation of this book (2014)
  2. Kumar, Abbas, Fausto, Aster: Robbins and Cotran Pathologic Basis of Disease. 9th edition, Elsevier Saunders, 2015

Lecture Contents

  • General Pathology
    • Introduction
    • Cellular damage
    • Metabolic disturbances
    • Circulatory disturbances
    • Inflammation, allergy and autoimmunity
    • Neoplasm
    • Birth defects and perinatal diseases
  • Systemic pathology
    • Hematopoietic system
    • Digestive system
    • Endocrine system
    • Mammary glands
    • Respiratory system
    • Nervous system
    • Genitourinary system (male and female)
    • Infectious diseases
    • Skin, bone and soft tissue
    • Circulatory system

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Page last updated June 25, 2015

The class contents were most recently updated on the date indicated. Please be aware that there may be some changes between the most recent year and the current page.

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